Analysis of the antifungal activity and bioactivity of gold nanoparticles conjugated with Os-C(W5)

These datasets consist of quantitative and qualitative data from the analysis of GNP@Os-C(W5) including spectrophotometry readings, scanning electron microscopy images and circular dichroism findings. A 535 nm band and GNPs of 13.2 ± 2.4 nm confirmed the successful synthesis of GNP@Os-C(W5). Circular dichroism identified that the secondary structure was disordered, similar to Os-C(W5). Anticandidal activity was reduced with a 50% minimum inhibitory concentration (MIC50) of 13.21 ± 0.148 μM for GNP@Os-C(W5) compared with 1.37 ± 0.076 μM for Os-C(W5) under the conditions used in this study. Additionally, the minimum fungicidal concentrations were 10 μM for Os-C(W5) and 34 μM for GNP@Os-C(W5) where the two were identified as fungistatic and fungicidal respectively. At the respective MIC50 values, both compounds caused membrane associated cellular damage. Furthermore, both were non-cytotoxic at 1.37 μM Os-C(W5) and 6.84 μM GNP@Os-C(W5) in human erythrocytes and leukocytes. For GNP@Os-C(W5) compared with Os-C(W5), antioxidant activity was reduced by several fold. Although the anticandidal activity of GNP@Os-C(W5) was reduced, the GNP conjugate showed greater resistance to trypsin degradation than melittin and Os-C(W5).