Effects of dolutegravir, efavirenz and co-trimoxazole on metabolomic, cytokine and platelet activation profiles in people living with HIV

<p>The datasets include an excel spreadsheet with all the raw data including the concentrations of cytokines ( IL-1β, IL-4, IL-6, IL-8, IL-10, TNF-α, IFN-γ and GM-CSF), platelet activation markers (sCD40L and RANTES), as well as identified matabolites. Tables also included paired analyses after six months of treatment and heatmaps visually present concentrations.</p> <p>Samples were collected from efavirenz treatment experianced participants (at baseline), before treatment initiation, as well as six months after treatment initiation with a placebo, prophylactic co-trimoxazole or dolutegravir. Techniques used include nuclear magnetic resonance, bead-based suspention arrays and enzyme-linked immunosorbant assays. Participants had to be 18 years and older to be included in the study.</p> <p><br></p>