Datasets involved in the investigation on the effect of vitamin D supplementation on clotting parameters and morphology in prostate cancer patients. Datasets underpin the study "The effect of the ex vivo addition of vitamin D on the prothrombotic and fibrinolytic potential in prostate cancer patints' blood". The study investigated the hypercoagulable state of both metastatic and nonmetastatic PCa patients, in comparison to a reference group, before and after the ex vivo supplementation with vitamin D.