Michael Pepper

Publications

• Precision global health: a roadmap for augmented action
• When cells become medicines: A South African perspective
• Method and kit for identifying gene mutations
• The Role of Pref-1 during Adipogenic Differentiation: An Overview of Suggested Mechanisms
• The Effect of Early Rounds of ex vivo Expansion and Cryopreservation on the Adipogenic Differentiation Capacity of Adipose-Derived Stromal/Stem Cells
• Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways
• The effect of medium supplementation and serial passaging on the transcriptome of human adipose-derived stromal cells expanded in vitro
• Spectrum of MYO7A Mutations in an Indigenous South African Population Further Elucidates the Nonsyndromic Autosomal Recessive Phenotype of DFNB2 to Include Both Homozygous and Compound Heterozygous Mutations
• An optimistic vision for biosciences in South Africa: Reply to Thaldar et al. (2019)
• An In Vitro and In Vivo Comparison of Osteogenic Differentiation of Human Mesenchymal Stromal/Stem Cells
• Fate of systemically and locally administered adipose‐derived mesenchymal stromal cells and their effect on wound healing
• Barriers to Implementing Clinical Pharmacogenetics Testing in Sub-Saharan Africa. A Critical Review
• Establishment and equilibrium levels of deleterious mutations in large populations
• Lessons Learned from Somatic Cell Nuclear Transfer
• Similarities between Tumour Immune Response and Chronic Wound Microenvironment: Influence of Mesenchymal Stromal/Stem Cells
• A COVID-19 Vaccine: Big Strides Come with Big Challenges
• Characterization of Signalling Pathways That Link Apoptosis and Autophagy to Cell Death Induced by Estrone Analogues Which Reversibly Depolymerize Microtubules
• Author Correction: Establishment and equilibrium levels of deleterious mutations in large populations
• Molecular mechanisms underpinning sarcomas and implications for current and future therapy
• Single-Cell Transcriptome Analysis of Human Adipose-Derived Stromal Cells Identifies a Contractile Cell Subpopulation
• Sexual Dimorphism in Changes That Occur in Tissues, Organs and Plasma during the Early Stages of Obesity Development
• Slc7a8 deletion is protective against diet-induced obesity and attenuates lipid accumulation in multiple organs
• Paediatric inflammatory multisystem syndrome: What should we look out for in South Africa?
• Enabling the use of health data for research: Developing a POPIA code of conduct for research in South Africa
• Privacy rights of human research participants in South Africa must be taken seriously
• Development of an off-the-shelf CAR T-cell therapy for HIV: a step towards a universally accessible advanced therapy
• LANCE
• Letter to the editor: Privacy rights of human research participants in South Africa must be taken seriously
• Privacy rights of human research participants in South Africa must be taken seriously
• Perspectives on establishing a public cord blood inventory in South Africa
• Inclusivity and diversity: Integrating international perspectives on stem cell challenges and potential
• Resource allocation during covid-19: A focus on vulnerable populations
• The Deep Genome Project
• Access to novel therapies for COVID-19-distributive justice and Russian roulette?
• A prospective observational study of developmental outcomes in survivors of neonatal hypoxic ischaemic encephalopathy in South Africa
• Rapid evolution of our understanding of the pathogenesis of COVID-19 - implications for therapy
• The Genetic Discrimination Observatory: confronting novel issues in genetic discrimination
• Viruses, variants and vaccines
• Paediatric inflammatory multisystem syndrome: What should we look out for in South Africa?
• The COVID-19 Treatment Landscape: A South African Perspective on a Race Against Time
• Amplification of 3q26.2, 5q14.3, 8q24.3, 8q22.3, and 14q32.33 Are Possible Common Genetic Alterations in Oral Cancer Patients
• Research in COVID-19 times: The way forward
• The impact of obesity on the cellular and molecular pathophysiology of COVID-19
• Contact tracing during the covid-19 pandemic: Protection of personal information in south africa
• Lessons learned from somatic cell nuclear transfer
• Who is responsible for protecting my health during the COVID- 19 pandemic?
• Who is responsible for protecting my health during the COVID- 19 pandemic?
• Mesenchymal Stromal Cells: a Possible Reservoir for HIV-1?
• Step-by-step assembly and testing of a low-cost bioprinting solution for research and educational purposes
• Equitable access to cell and gene therapies in South Africa: opportunities and hurdles
• Deoxyribonucleic Acid Damage and Repair: Capitalizing on Our Understanding of the Mechanisms of Maintaining Genomic Integrity for Therapeutic Purposes
• The African Genomic Medicine Training Initiative (AGMT): showcasing a community and framework driven genomic medicine training for nurses in Africa
• Effect of genetic variation in UGT1A and ABCB1 on moxifloxacin pharmacokinetics in South African patients with tuberculosis
• Haematopoietic stem cell transplantation in South Africa: Current limitations and future perspectives
• Stem cell tourism and spinal cord injury in South Africa
• Cell and gene therapy–New medicines on the horizon
• Abstract B36: Contrasting views on the role of mesenchymal stem cells in tumor progression: A systematic review
• Clinical Safety and Applications of Stem Cell Gene Therapy
• 12.30 In Vivo Tracking Of Adipose-Derived Mesenchymal Stromal Cells During Physiological Wound Repair
• Establishment and equilibrium levels of deleterious mutations in large populations
• Cystic Fibrosis in the African Diaspora
• Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion
• Reactive Oxygen Species and NOX Enzymes Are Emerging as Key Players in Cutaneous Wound Repair
• Application of the AMLprofiler Diagnostic Microarray in the South African Setting
• The Role of Tumor Microenvironment in Chemoresistance: To Survive, Keep Your Enemies Closer
• Human Leukocyte Antigen-A, B, C, DRB1, and DQB1 Allele and Haplotype Frequencies in a Subset of 237 Donors in the South African Bone Marrow Registry
• Factors Influencing the Umbilical Cord Blood Stem Cell Industry: An Evolving Treatment Landscape
• An in vitro and in vivo study on the properties of hollow polycaprolactone cell-delivery particles
• Cystic fibrosis in South Africa: A changing diagnostic paradigm
• Exporting DNA – Striking a balance between preventing exploitation and promoting innovation
• Effect of genetic variation in UGT1A and ABCB1 on moxifloxacin pharmacokinetics in South African patients with tuberculosis
• AMLprofiler: A diagnostic and prognostic microarray for acute myeloid leukemia
• ASSAf consensus study on the ethical, legal and social implications of genetics and genomics in South Africa
• Side Population: Its Use in the Study of Cellular Heterogeneity and as a Potential Enrichment Tool for Rare Cell Populations
• Special edition of the SAMJ devoted to cell and gene therapy
• Primary immunodeficiency in Africa–a review
• Non‐nucleoside reverse transcriptase inhibitor levels among HIV‐exposed uninfected infants at the time of HIV PCR testing–findings from a tertiary healthcare facility in …
• Molecular profile of tongue cancer in an 18‐year‐old female patient with no recognizable risk factor
• Erratum: Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort
• Genome technologies, precision medicine and innovative therapies
• Comparison of human platelet lysate alternatives using expired and freshly isolated platelet concentrates for adipose-derived stromal cell expansion
• Molecular profile of tongue cancer in an 18-year-old female patient with no recognizable risk factor
• Stem cell therapy for neurological disorders
• Cell and gene therapies at the forefront of innovative medical care: Implications for South Africa
• Reference Gene Expression in Adipose-Derived Stromal Cells Undergoing Adipogenic Differentiation
• Safeguarding the future of genomic research in South Africa: Broad consent and the Protection of Personal Information Act No. 4 of 2013
• Ethical considerations in the application of cell and gene therapies in children
• Cancer stem cells in head and neck carcinomas: Identification and possible therapeutic implications
• The role of reactive oxygen species in adipogenic differentiation
• Contrasting views on the role of mesenchymal stromal/stem cells in tumour growth: A systematic review of experimental design
• Transplantation of gene-modified haematopoietic stem cells: Application and clinical considerations
• Non-nucleoside reverse transcriptase inhibitor levels among HIV-exposed uninfected infants at the time of HIV PCR testing – findings from a tertiary healthcare facility in Pretoria, South Africa
• HIV and haematopoiesis
• An early infant HIV risk score for targeted HIV testing at birth
• Gene and cell therapy in South Africa: Current status and future prospects
• Heterozygosity of p16 expression in an oral squamous cell carcinoma with associated loss of heterozygosity and copy number alterations
• Human leukocyte antigen (HLA) diversity and clinical applications in South Africa
• Heterogeneity of cell therapy products
• Strategies for screening cord blood for a public cord blood bank in high HIV prevalence regions
• Transplantation of gene-modified haematopoietic stem cells: Application and clinical considerations
• Human tissue legislation in South Africa: Focus on stem cell research and therapy
• Isolation and characterization of adipose-derived stromal cells
• Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort
• Pharmacogenomics for infectious diseases in sub-Saharan Africa: successes and opportunities
• Ownership and human tissue–the legal conundrum: A response to Jordaan’s critique
• Supplementary Materials: Fibroblast-Derived Extracellular Matrix Induces Chondrogenic Differentiation in Human Adipose-Derived Mesenchymal Stromal/Stem Cells in Vitro
• CRISPR-Cas: Revolutionising genome engineering
• Impact of CYP2D6 genotype on amitriptyline efficacy for the treatment of diabetic peripheral neuropathy: A pilot study
• Erratum: Cystic fibrosis on the African continent (Genetics in Medicine (2015) DOi:10.1038/gim.2015.157)
• Evaluation of predictive CYP2C19 genotyping assays relative to measured phenotype in a South African cohort
• Homing properties of mesenchymal stromal cells
• Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort
• Pharmacogenomics for infectious diseases in sub-Saharan Africa: Successes and opportunities
• Cystic fibrosis on the African continent
• Biotechnology innovators to convene in Cape Town, South Africa: Pharmacogenetics and precision medicine conference (April 7-9, 2016)
• Ownership and human tissue – The legal conundrum: A response to Jordaan’s critique
• Pharmacogenomics and global precision medicine in the context of adverse drug reactions: Top 10 opportunities and challenges for the next decade
• Altered expression of platelet factor 4 and basic fibroblast growth factor correlates with the inhibition of tumor growth in mice
• Wharton's Jelly-Derived Mesenchymal Stromal Cells and Fibroblast-Derived Extracellular Matrix Synergistically Activate Apoptosis in a p21-Dependent Mechanism in WHCO1 and MDA MB 231 Cancer Cells in Vitro
• The state of gene therapy research in Africa, its significance and implications for the future
• Implications of direct-to-consumer whole-exome sequencing in South Africa
• Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans
• HLA typing: Conventional techniques v. next-generation sequencing
• Social justice and research using human biological material: A right to respond
• Human leukocyte antigen diversity: A Southern African perspective
• Mitochondrial transfer: Implications for assisted reproductive technologies
• Genome-wide analysis of gene expression during adipogenesis in human adipose-derived stromal cells reveals novel patterns of gene expression during adipocyte differentiation
• Constituting a public umbilical cord blood bank in South Africa
• Biocompatibility and biodegradation of protein microparticle and film scaffolds made from kafirin (sorghum prolamin protein) subcutaneously implanted in rodent models
• Novel fl ow cytometric approach for the detection of adipocyte subpopulations during adipogenesis
• The FitTrack Index as fitness indicator: A pilot study
• Could we offer mitochondrial donation or similar assisted reproductive technology to South African patients with mitochondrial DNA disease?
• Identification of transcription factors potentially involved in human adipogenesis in vitro
• Gender and sexual diversity – changing paradigms in an ever-changing world
• Fibroblast-derived extracellular matrix induces chondrogenic differentiation in human adipose-derived mesenchymal stromal/stem cells in vitro
• Human adipose derived mesenchymal stromal cells transduced with GFP lentiviral vectors: assessment of immunophenotype and differentiation capacity in vitro
• Stem Cell Therapy: Accepted Therapies, Managing the Hope of Society, and a Legal Perspective
• Cord blood stem cell banking
• Harvesting and collection of adipose tissue for the isolation of adipose-derived stromal/stem cells
• Journal of Medical Law and Ethics
• Isolation and characterization of human adipose derived mesenchymal stem cells and production of GFP-labeled primary cells for in vivo tracking following transplantation
• Manipulating the Tumor Microenvironment: Opportunities for Therapeutic Targeting
• Challenges raised by gene editing
• Transgenic cell selection
• Novel flow cytometric approach for the detection of adipocyte subpopulations during adipogenesis [S]
• A global comparative overview of the legal regulation of stem cell research and therapy: lessons for South Africa: legislation
• Pharmacogenomics and global precision medicine in the context of adverse drug reactions: top 10 opportunities and challenges for the next decade
• Making the switch: Alternatives to fetal bovine serum for adipose-derived stromal cell expansion
• Allelic variants of the melanocortin 4 receptor (MC4R) gene in a South African study group
• 448. Lentivector Knock-Down of CCR5 in Hematopoietic Stem Cells Confers Functional and Persistent HIV-1 Resistance in Humanized Mice
• Progresses towards safe and efficient gene therapy vectors
• CC chemokine receptor type five (CCR5): an emerging target for the control of HIV infection
• Introduction of the AmpliChip CYP450 Test to a South African cohort: a platform comparative prospective cohort study
• Inhibition of hemangioma development in a syngeneic mouse model correlates with bcl-2 suppression and the inhibition of Akt kinase activity
• Opportunities and barriers to establishing a cell therapy programme in South Africa
• Enactment of Chapter 8 of the National Health Act and regulations thereto
• Legislation governing pluripotent stem cells in South Africa
• Lentivector knockdown of CCR5 in hematopoietic stem and progenitor cells confers functional and persistent HIV-1 resistance in humanized mice
• Ethical, legal and social issues in the context of the planning stages of the Southern African Human Genome Programme.
• Cardiovascular pharmacogenetics
• Pharmacogenetics of CYP2B6, CYP2A6 and UGT2B7 in HIV treatment in African populations: Focus on efavirenz and nevirapine
• Introduction of the AmpliChip CYP450 Test to a South African cohort: A platform comparative prospective cohort study
• The correlation between the health-related fitness of healthy participants measured at home as opposed to fitness measured by sport scientists in a laboratory
• Understanding the implications of mitochondrial DNA variation in the health of black southern african populations: The 2014 workshop
• Inhibition of hemangioma development in a syngeneic mouse model correlates with bcl-2 suppression and the inhibition of Akt kinase activity
• Mutations in C-C chemokine receptor type 5 (CCR5) in South African individuals
• Establishing a public umbilical cord blood stem cell bank for south africa: An enquiry into public acceptability
• University entrepreneurship in South Africa: Developments in technology transfer practices
• C-C chemokine receptor type five (CCR5): An emerging target for the control of HIV infection
• Curbing stem cell tourism in south africa
• Progresses towards safe and efficient gene therapy vectors
• Primary and secondary coenzyme Q10 deficiency: The role of therapeutic supplementation
• Adipocyte and adipogenesis
• Genomic sovereignty and the african promise: Mining the African genome for the benefit of Africa
• Cytochrome P450 pharmacogenetics in African populations
• IL-27 Inhibits lymphatic endothelial cell proliferation by STAT1-regulated gene expression
• The role of reactive oxygen species in mesenchymal stem cell adipogenic and osteogenic differentiation: A review
• Lentivector knockdown of CCR5 in hematopoietic stem and progenitor cells confers functional and persistent HIV-1 resistance in humanized mice
• The potential of stem cells in the treatment of cardiovascular diseases
• Priority pharmacogenetics for the African continent: Focus on CYP450
• Special issue - Pharmacogenomics & personalized medicine, journal of applied and translational genomics
• Risperidone-associated adverse drug reactions and CYP2D6 polymorphisms in a South African cohort
• Opportunities and barriers to establishing a cell therapy programme in South Africa
• Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation
• Priority pharmacogenetics for the African continent: focus on CYP450
• Mitochondrial transfer: Ethical, legal and social implications in assisted reproduction
• Journal of Medical Law and Ethics
• The effect of hyperbaric oxygen and blood platelet injection therapy on the healing of hamstring injuries in rugby players
• Kalvyn Schoeman van Eeden-obituary: izindaba
• Journal of Medical Law and Ethics
• Evaluation Of The AMLprofiler in The South African Context: Report On Preliminary Findings
• SAJBL: Flagship special stem cell edition
• Stem cell tourism in South Africa: a legal update: stem cell tourism
• Pharmacogenetics of CYP2B6, CYP2A6 and UGT2B7 in HIV treatment in African populations: focus on efavirenz and nevirapine
• Mutations in CC chemokine receptor type 5 (CCR5) in South African individuals
• Seminar: Inflammation, obesity and diabetes: a novel face of a fragile balance
• The legal position on the classification of human tissue in South Africa: Can tissues be owned?
• PRIORITY PHARMACOGENETICS FOR AFRICA: ESTABLISHMENT OF A PAN-AFRICAN INITIATIVE: 554
• Pharmacogenomics & personalized medicine, Journal of Applied and Translational Genomics
• mTOR/PI3k/Akt SIGNALING PATHWAY IN TUMOR ANGIOGENESIS AND THERAPEUTIC TARGETING
• Launch of the Southern African Human Genome Programme: correspondence
• Methods and Compositions for Directing Migration of Neural Progenitor Cells
• Preface-Angiogenesis in development and cancer today.
• The application of the Consumer Protection Act in the South African health care context: concerns and recommendations
• PHARMACOGENETICS AND PHARMACOGENOMICS IN THE DEVELOPING WORLD
• Abstract# 2002: VEGFR-3 and Prox1 are elevated by NF-\# 954; B during inflammatory lymphangiogenesis
• Research Note: Technology Transfer Practices at South African Universities and Science Councils
• The healing power of stem cells: why we need rules: correspondence
• Cell-based therapy - navigating troubled waters
• The genetics of obesity: The role of the melanocortin 4 receptor
• Launch of the Southern African Human Genome Programme
• The human genome and molecular medicine -promises and pitfalls
• The stem cell regulatory environment in South Africa - Cause for concern
• The Consumer Protection Act: No-fault liability of health care providers
• Partial relief from the regulatory vacuum involving human tissues through enactment of chapter 8 of the National Health Act and regulations thereto
• Mixed Arterio-Venous Insufficiency in Random Skin Flaps in the Rat: Is the Application of Medicinal Leeches Beneficial?
• Quantitative plasma analysis using automated online solid-phase extraction with column switching LC-MS/MS for characterising cytochrome P450 2D6 and 2C19 metabolism
• IL-20 activates human lymphatic endothelial cells causing cell signalling and tube formation
• Stem cell research engenders interdisciplinary collaboration in science, ethics and religion
• Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-κB and Prox1
• A comparative study on the anti-angiogenic effects of DNA-damaging and cytoskeletal-disrupting agents
• The healing power of stem cells: Why we need rules
• Regaining perspective on stem cells
• Pharmacogenomic research in South Africa: Lessons learned and future opportunities in the rainbow nation
• Lymphatic endothelial cells: establishment of primaries and characterization of established lines.
• The lymphatic vascular system in lymphangiogenesis invasion and metastasis a mathematical approach
• Human lymphatic endothelial cells express multiple functional TLRs
• Hemangiomas - current therapeutic strategies
• Lymphatic expression of CLEVER-1 in breast cancer and its relationship with lymph node metastasis
• Pilot Social Feasibility Study for the Establishment of a Public Human Umbilical Cord Blood Stem Cell Bank in South Africa
• Banning private stem cell banks: A human rights analysis
• Hypoxic preconditioning increases skin oxygenation and viability but does not alter VEGF expression or vascular density
• Circulating and imaging markers for angiogenesis
• Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-κB and Prox1
• Is South Africa on the verge of a medical malpractice litigation storm?
• Pilot social feasibility study for the establishment of a public human umbilical cord blood stem cell bank in South Africa
• Role of CLEVER-1 in breast cancer metastasis
• Stem cells: current reality & future promise
• The application of the Consumer Protection Act in the South African health care context: concerns and recommendations
• EVALUATION OF THE ANTIANGIOGENIC EFFECTS OF BLEOMYCIN IN VITRO
• " A room of our own?" Legal lacunae regarding genomic sovereignty in South Africa
• Early changes following bariatric surgery in South Africa
• Pharmacogenomic research in South Africa: lessons learned and future opportunities in the rainbow nation
• A Room of Our Own: Legal Lacunae regarding Genomic Sovereignty in South Africa
• Partial relief from the regulatory vacuum involving human tissues through enactment of chapter 8 of the National Health Act and regulations thereto
• Medicine and the law: Partial relief from the regulatory vacuum involving human tissues through enactment of chapter 8 of the National Health Act and regulations thereto
• Myofibroblasts Play A Key Role In Delayed Wound Healing In Ischemia: OP17–3
• FOCUSED CONFERENCE GROUP: P13-MAXIMISING BENEFITS AND MINIMIZING HARMS FROM DRUGS CYP2D6 AND CYP2C19: A COMPARISON OF DIRECT VERSUS PREDICTED PHENOTYPING IN A SOUTH AFRICAN …
• AmpliChip CYP450 genotype profiling for improving treatment outcomes in psychiatric patients
• O-87 The role of CLEVER-1 in breast tumour metastasis
• Obesity in South Africa
• Involvement of the VEGF receptor 3 in tubular morphogenesis demonstrated with a human anti-human VEGFR-3 monoclonal antibody that antagonizes receptor activation by VEGF-C
• Lymphangiogenesis and tumour metastasis
• Novel tempeh (fermented soyabean) isoflavones inhibit in vivo angiogenesis in the chicken chorioallantoic membrane assay
• Sustained weight loss after an 18 month period of intensive obesity intervention and the successful use of pro-BNP to exclude cardiac disease
• Persistent Ischemia Impairs Myofibroblast Development in Wound Granulation Tissue a New Model of Delayed Wound Healing
• RAPID AND SHORT COMMUNICATIONS-Downregulation of vascular endothelial-cadherin expression is associated with an increase in vascular tumor growth and hemorrhagic complications
• Lymphatic vessel density and VEGF-C expression correlate with malignant behavior in human pancreatic endocrine tumors
• Polymorphisms in the endothelial nitric oxide synthase gene and the tendency for aneurysm rupture
• Sustained weight loss after an 18-month period of intensive obesity intervantion and the successful use of pro-BNP to exclude cardiac disease
• Le rôle des récepteurs à VEGF dans la régulation de l'angiogenèse
• Discussion
• Discussion
• General discussion I
• Discussion
• Discussion
• Final general discussion
• Discussion
• Discussion
• Lymphangiogenesis and tumour metastasis
• Discussion
• Lymphatic vessel density in the neoplastic progression of Barrett's oesophagus to adenocarcinoma
• Expression and localization of VEGF-C and VEGFR-3 in glioblastomas and haemangioblastomas
• Lymphangiogenesis in human gynaecological cancers
• Lymphatic vessel density and vascular endothelial growth factor-C expression correlate with malignant behavior in human pancreatic endocrine tumors
• Active-site inactivated FVIIa decreases thrombosis and necrosis in a random skin flap model of acute ischemia
• Generation and characterization of telomerase-transfected human lymphatic endothelial cells with an extended life span
• Hereditary vascular anomalies: New insights into their pathogenesis
• Tetracycline-regulated expression of VEGF-A in beta cells induces angiogenesis: Improvement of engraftment following transplantation
• Involvement of the VEGF receptor 3 in tubular morphogenesis demonstrated with a human anti-human VEGFR-3 monoclonal antibody that antagonizes receptor activation by VEGF-C
• Polymorphisms in the endothelial nitric oxide synthase gene and the tendency for aneurysm rupture
• Immunohistochemical quantification of lymph vessels, VEGF-C and VEGF receptor 3 in human sarcomas [1]
• Bovine microvascular endothelial cells immortalized with human telomerase
• 8-Prenylnaringenin, a Novel Phytoestrogen, Inhibits Angiogenesis in Vitro and in Vivo
• Membrane-type-1 matrix metalloproteinase confers tumorigenicity on nonmalignant epithelial cells
• Obesity in South Africa
• Novel tempeh (fermented soyabean) isoflavones inhibit in vivo angiogenesis in the chicken chorioallantoic membrane assay
• Persistent ischemia impairs myofibroblast development in wound granulation tissue: A new model of delayed wound healing
• First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours
• Downregulation of vascular endothelial-cadherin expression is associated with an increase in vascular tumor growth and hemorrhagic complications
• Progressive tissue injury in burns is reduced by rNAPc2
• Interferon alpha And Bleomycin exert Antiangiogenic Activity Through Different Mechanisms
• FAMILIAL PREDISPOSITION TO TUFTED ANGIOMA: IDENTIFICATION OF BLOOD AND LYMPHATIC VASCULAR COMPONENTS
• Ets 1 is expressed in capillary blood vessels but not in lymphatics
• Persistent ischemia impairs myofibroblast development in wound granulation tissue: a new model of delayed wound healing
• Progressive tissue injury in burns is reduced by rNAPc2
• HETEROGENEITY OF SMOOTH MUSCLE CELL POPULATIONS CULTURED FROM PIG CORONARY ARTERY
• Haemangiomas are formed by cells expressing high levels of α vβ3 integrin and lacking acetylated LDL uptake
• Dissecting the role of matrix metalloproteinases (MMP) and integrin αvβ3 in angiogenesis in vitro: Absence of hemopexin C domain bioactivity, but membrane-type 1-MMP and α vβ3 are critical
• Altered signalling of an inhibitory VEGF-A splice variant results from a defect in heparin binding; implications for angiogenesis in development and tissue repair: C3-016P
• Porcine coronary artery smooth muscle cells are phenotypically heterogeneous
• Overexpression of Vascular Endothelial Growth Factor-A165 Enhances Tumor Angiogenesis but not Metastasis during...
• Regulated gene expression of VEGF-164 by pancreatic beta-cells improves revascularization and engraftment after transplantation
• VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) RECEPTOR-2 SIGNALING MEDIATES VEGF-CΔNΔC-AND VEGF-A-INDUCED ANGIOGENESIS IN VITRO
• VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) RECEPTOR-2 ANTAGONISTS INHIBIT VEGF-AND BASIC FIBROBLAST GROWTH FACTOR-INDUCED ANGIOGENESIS IN VIVO AND IN VITRO
• Angiogenesis-regulating cytokines
• Capillary morphogenesis in vitro: cytokine interactions and balanced proteolysis
• Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-CΔNΔC-and VEGF-A-induced angiogenesis in vitro
• Regular Articles-Tumor Biology-Overexpression of Vascular Endothelial Growth Factor-A165 Enhances Tumor Angiogenesis but not Metastasis during b-Cell Carcinogenesis.
• CANCER DIAGNOSIS AND THERAPY-Lectin-deficient TNF mutants display comparable tumour but reduced pro-metastatic potential as compared to the wild-type molecule Published online …
• Growth Factor Regulation of Physiologic Angiogenesis in the Mammary Gland
• Extracellular proteolysis and angiogenesis
• Lymphangiogenesis and tumor metastasis
• Overexpression of vascular endothelial growth factor-A165 enhances tumor angiogenesis but not metastasis during β-cell carcinogenesis
• Erratum: Molecular characterization of lymphatic endothelial cells (Proceedings of the National Academy of Sciences of the United States of America (December 10, 2002) 99: 25 (16069-16074))
• Increased angiostatin levels in bronchoalveolar lavage fluids from ARDS patients and from human volunteers after lung instillation of endotoxin
• αvβ3 and αvβ5 integrin antagonists inhibit angiogenesis in vitro
• Lymphatic dissemination of tumour cells and the formation of micrometastases
• Visualizing function in the tumor-associated lymphatic system
• Ets I is expressed in capillary blood vessels but not in lymphatics
• Delivery of FGF-2 but not VEGF by encapsulated genetically engineered myoblasts improves survival and vascularization in a model of acute skin flap ischemia
• Lymphatic endothelium: Morphological, molecular and functional properties
• Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2
• Heterogeneity of smooth muscle cell populations cultured from pig coronary artery
• FGF-2 promotes disassembly of actin cytoskeleton and shape changes in murine vascular cells
• Familial predisposition to tufted angioma: Identification of blood and lymphatic vascular components
• Microscopy: An art?
• Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-CΔNΔC- and VEGF-A-induced angiogenesis in vitro
• A model for co-expression pattern analysis of genes implicated in angiogenesis and tumour cell invasion in cervical cancer
• Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D, and their receptor VEGFR-3, during different stages of cervical carcinogenesis
• VEGF is a chemoattractant for FGF-2-stimulated neural progenitors
• Literature watch. FOXC2 haploinsufficient mice are a model for human autosomal dominant lymphedema-distichiasis syndrome.
• Mesenchymal cells potentiate vascular endothelial growth factor-induced angiogenesis in vitro
• Molecular characterization of lymphatic endothelial cells
• Lymphangiogenesis and tumor metastasis
• Molecular characterization of lymphatic endothelial cells
• Literature Watch
• Molecular characterization of lymphatic endothelial cells (vol 99, pg 16069, 2002)
• Molecular characterization of lymphatic endothelial cells
• human VEGFR-3 monoclonal antibody that antagonizes receptor activation by VEGF-C
• Lymphatic endotheliumAbbreviations used in this paper: BEC, blood endothelial cell; CCL, chemokine ligand; CCR, chemokine receptor; CLEVER-1, common lymphatic endothelial and …
• RETROVIRAL TRANSDUCTION OF PANCREATIC BETACELLS BY VEGF-164 IMPROVES GLYCEMIC CONTROL IN A SYNGENEIC MODEL OF ISLET CELL TRANSPLANTATION: 0129
• Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids
• Overexpression of vascular endothelial growth factor-A165 enhances tumor angiogenesis but not metastasis during β-cell carcinogenesis
• Inhibition of endothelial wound repair by dominant negative connexin inhibitors
• MESENCHYMAL CELLS POTENTIATE VASCULAR ENDOTHELIAL GROWTH FACTOR-INDUCED ANGIOGENESIS IN VITRO
• Ets 1 and lymphangiogenesis
• Increased angiostatin levels in bronchoalveolar lavage fluids from ARDS patients and from human volunteers after lung instillation of endotoxin
• Role of the Plasminogen Activator-Plasmin System in Angiogenesis
• 2 Angiogenesis-Regulating Cytokines
• Vascular endothelial growth factor (VEGF) receptor-2 antagonists inhibit VEGF-and basic fibroblast growth factor-induced angiogenesis in vivo and in vitro
• Lymphangiogenesis and biological activity ov vascular endothelial growth factor-C
• Posttranscriptional stimulation of endothelial cell matrix metalloproteinases 2 and 1 by endothelioma cells
• Original Contributions-Vascular Biology-Regulation of Angiopoietin-2 mRNA Levels in Bovine Microvascular Endothelial Cells by Cytokines and Hypoxia
• REVIEW ARTICLES-Vascular angiogenesis and morphogenesis of the vascular tree from cell biology to clinical findings
• Vascular angiogenesis and morphogenesis of the vascular tree: From cell biology to clinical findings,Angiogenese et morphogenese de l'arbre vasculaire: De la biologie cellulaire a la clinique
• Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis
• Lymphangiogenesis and tumor metastasis: Myth or reality?
• Synergistic induction of t-PA by vascular endothelial growth factor and basic fibroblast growth factor and localization of t-PA to Weibel-Palade bodies in bovine microvascular endothelial cells
• Constitutively active mitogen-activated protein kinase kinase MEK1 disrupts morphogenesis and induces an invasive phenotype in Madin-Darby canine kidney epithelial cells
• Lymphangiogenesis and tumor metastasis: More questions than answers
• FGF-2 stimulates migration of Kaposi's sarcoma-like vascular cells by HGF-dependent relocalization of the urokinase receptor
• Synergistic induction of t-PA by VEGF and bFGF and localization of t-PA to WeibelPalade bodies in bovine microvascular endothelial (BME) cells
• Multiple forms of angiostatin induce apoptosis in endothelial cells
• Inducible and irreversible control of gene expression using a single transgene.
• Endothelial cell integrin α5β1 expression is modulated by cytokines and during migration in vitro
• Vascular endothelial growth factor (VEGF) receptor-2 antagonists inhibit VEGF- and basic fibroblast growth factor-induced angiogenesis in vivo and in vitro
• Characterization of novel clonal murine endothelial cell lines with an extended life span
• Lectin-deficient TNF mutants display comparable anti-tumour but reduced pro-metastatic potential as compared to the wild-type molecule
• Thrombospondin-1 is downregulated by anoxia and suppresses tumorigenicity of human glioblastoma cells
• Inhibition of endothelial wound repair by dominant negative connexin inhibitors
• Response of bovine endothelial cells to FGF-2 and VEGF is dependent on their site of origin: Relevance to the regulation of angiogenesis
• Regulation of VEGF and VEGF receptor expression in the rodent mammary gland during pregnancy, lactation, and involution
• Lymphangiogenesis and lymph node microdissemination
• Phytoestrogens and inhibition of angiogenesis
• Retinoic acid regulates arterial smooth muscle cell proliferation and phenotypic features in vivo and in vitro through an RARα-dependent signaling pathway
• Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis
• Elevated levels of angiogenic cytokines in the plasma of cancer patients
• New role for tRNA and its fragment purified from human urinary bladder carcinoma conditioned medium: Inhibition of endothelial cell growth
• Pediatric medulloblastoma: Prognostic value of p53, bcl-2, Mib-1, and microvessel density
• Plasminogen activator expression in rat arterial smooth muscle cells depends on their phenotype and is modulated by cytokines
• Both TNF receptors are required for direct TNF-mediated cytotoxicity in microvascular endothelial cells
• Posttranscriptional stimulation of endothelial cell matrix metalloproteinases 2 and 1 by endothelioma cells
• Expression of vascular endothelial growth factor in digestive neuroendocrine tumours
• Hypoxia-inducible angiopoietin-2 expression is mimicked by iodonium compounds and occurs in the rat brain and skin in response to systemic hypoxia and tissue ischemia
• Signalling properties of an HIV-encoded angiogenic peptide mimicking vascular endothelial growth factor activity
• Lymphangiogenesis and biological activity ov vascular endothelial growth factor-C,Lymphangiogenèse et activité biologique du facteur de croissance vasculaire endothélial-C.
• Chromogranin A alters ductal morphogenesis and increases deposition of basement membrane components by mammary epithelial cells in vitro
• 7Phytoestrogens and inhibition of angiogenesis
• Lectin‐deficient TNF mutants display comparable anti‐tumour but reduced pro‐metastatic potential as compared to the wild‐type molecule
• Angiogenèse et morphogenèse de l'arbre vasculaire: de la biologie cellulaire à la clinique.
• New role for tRNA and its fragment purified from human urinary bladder carcinoma conditioned medium: inhibition of endothelial cell growth
• Inducible and irreversible control of gene expression using a single transgene
• Vascular Morphogenesis in the Mammary Gland: Introduction and Overview
• Lymphangiogenèse et activité biologique du facteur de croissance vasculaire endothélial-C
• Tribute to Werner Risau: December 18, 1953–December 13, 1998
• Nasty Endings 2
• Pediatric medulloblastoma: prognostic value of p53, bcl-2, Mib-1, and microvessel density
• Multiple forms of angiostatin induce apoptosis in endothelial cells
• Plasminogen activator expression in rat arterial smooth muscle cells depends on their phenotype and is modulated by cytokines
• Inhibition of angiogenesis by tissue inhibitor of metalloproteinase-3.
• Three-dimensional in vitro assay of endothelial cell invasion and capillary tube morphogenesis
• VEGF-B binds to VEGFR-1 and regulates plasminogen activator activity in endothelial cells
• Inhibitors of angiogenesis in human urine
• Modulation of clusterin gene expression in the rat mammary gland during pregnancy, lactation, and involution
• Facts and faces
• ANGIOGENESIS: A BALANCE BETWEEN POSITIVE & NEGATIVE REGULATORS: 214
• Endothelial cells from human blood capillaries also express the epidermal fatty acid-binding protein.
• Angiogenesis-regulating cytokines: Activities and interactions
• Hémangiomes et malformations vasculaires : Casuistique d'une consultation multidisciplinaire hemangiomas and vascular malformations: experience of a multidisciplinary consultation
• Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis
• Inhibition of angiogenesis by tissue inhibitor of metalloproteinase-3
• Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells
• Leukemia inhibitory factor (LIF) inhibits angiogenesis in vitro
• An antisense oligonucleotide to the notch ligand jagged promotes angiogenesis in bovine micro vascular endothelial cells (BMEC) on collagen gels
• Vascular endothelial growth factor-induced in vitro angiogenesis and plasminogen activator expression are dependent on endogenous basic fibroblast growth factor
• Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis
• Synergistic effect of hyaluronan oligosaccharides and vascular endothelial growth factor on angiogenesis in vitro
• Vascular endothelial growth factor is increased in devascularized rat islets of Langerhans in vitro
• An antisense oligonucleotide to the Notch ligand Jagged enhances fibroblast growth factor-induced angiogenesis in vitro
• In vitro angiogenic and proteolytic properties of bovine lymphatic endothelial cells
• Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells
• Biphasic effect of transforming growth factor-β1on in vitro angiogenesis
• Endothelial cells of the human microvasculature express epidermal fatty acid-binding protein
• Modulation of clusterin gene expression in the rat mammary gland during pregnancy, lactation, and involution
• Polyoma middle T-induced vascular tumor formation: The role of the plasminogen activator/plasmin system
• Vascular endothelial growth factor (VEGF)-C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity
• Regulation of vascular endothelial growth factor receptor-2 (Flk-1) expression in vascular endothelial cells
• Transforming growth factor β1 down-regulates vascular endothelial growth factor receptor 2/flk-1 expression in vascular endothelial cells
• Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells
• Membrane proteases in focus
• Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia
• Roles of Hepatocyte Growth Factor/Scatter Factor and Transforming Growth Factor-β1in Mammary Gland Ductal Morphogenesis
• PDGF-BB increases endothelial migration and cord movements during angiogenesis in vitro
• Angiogenesis: A paradigm for balanced extracellular proteolysis during cell migration and morphogenesis
• The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth
• Modulation of bovine microvascular endothelial cell proteolytic properties by inhibitors of angiogenesis
• Manipulating angiogenesis: From basic science to the bedside
• Induction of epithelial branching tubulogenesis in vitro
• Positive and negative regulation of angiogenesis: From cell biology to the clinic
• Modulationof hepatocyte growth factor and c-met in the rat mammary gland during pregnancy, lactation, and involution
• Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity
• PDGF‐BB increases endothelial migration and cord movements during angiogenesis in vitro
• Induction of epithelial branching tubulogenesis in vitro
• Angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis
• Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids
• MODULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION IN ISOLATED ISLETS OF LANGERHANS: 219
• Endothelial cells from human skin express epidermal fatty acid-binding protein (E-FABP).
• REGULATION OF ANGIOGENESIS IN-VITRO-CYTOKINE INTERACTIONS AND BALANCED EXTRACELLULAR PROTEOLYSIS
• Endothelial cells transformed by polyoma virus middle T oncogene: a model for hemangiomas and other vascular tumors
• Proteolytic balance and capillary morphogenesis in vitro
• Dance: A suitable form of exercise? A physiological appraisal
• Modulation of angiogenesis in vitro.
• Paracrine induction of angiogenesis in vitro by Swiss 3T3 fibroblasts
• Coupling and connexin 43 expression in microvascular and large vessel endothelial cells
• Proteolytic balance and capillary morphogenesis in vitro.
• Hepatocyte growth factor increases urokinase-type plasminogen activator (u-PA) and u-PA receptor expression in Madin-Darby canine kidney epithelial cells
• Plasminogen activator inhibitor‐1 is induced in migrating endothelial cells
• Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells
• Upregulation of urokinase receptor expression on migrating endothelial cells
• Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro
• Differential expression of gap junction connexins in endocrine and exocrine glands
• Urokinase-type plasminogen activator is induced in migrating capillary endothelial cells
• Proteolytic balance and capillary morphogenesis
• Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro
• In vivo modulation of connexin 43 gene expression and junctional coupling of pancreatic B-cells
• Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene
• Chondrocytes inhibit endothelial sprout formation in vitro: Evidence for involvement of a transforming growth factor‐beta
• Genistein, a dietary-derived inhibitor of in vitro angiogenesis
• Junctional communication is induced in migrating capillary endothelial cells
• Induction of angiogenesis in vitro by vanadate, an inhibitor of phosphotyrosine phosphatases
• Basic fibroblast growth factor increases junctional communication and connexin 43 expression in microvascular endothelial cells
• Phorbol ester induces cultured endothelial cells to invade a fibrin matrix in the presence of fibrinolytic inhibitors
• Plasminogen activator inhibitor-1 is induced in microvascular endothelial cells by a chondrocyte-derived transforming growth factor-beta
• Modulation of angiogenesis in vitro
• Angiogenesis InVitro: Morphogenetic and Invasive Properties of Endothelial Cells
• Angiogenesis in vitro: interactions between angiogenesis-modulating cytokines and the role of balanced extracellular proteolysis
• Invasive properties of endothelial cells: contributions to the process of angiogenesis
• ENDOTHELIAL CELL-MATRIX INTERACTIONS IN ANGIOGENESIS
• Proteolytic balance and capillary morphogenesis in vitro
• Slc7a8 Deletion Is Protective against Diet-Induced Obesity and Attenuates Lipid Accumulation in Multiple Organs
• Social Media and COVID-19—Perceptions and Public Deceptions of Ivermectin, Colchicine and Hydroxychloroquine: Lessons for Future Pandemics
• Special issue - Pharmacogenomics & personalized medicine, journal of applied and translational genomics
• Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-CΔNΔC- and VEGF-A-induced angiogenesis in vitro
• Dissecting the role of matrix metalloproteinases (MMP) and integrin αvβ3 in angiogenesis in vitro: Absence of hemopexin C domain bioactivity, but membrane-type 1-MMP and α vβ3 are critical
• Haemangiomas are formed by cells expressing high levels of α vβ3 integrin and lacking acetylated LDL uptake
• Roles of Hepatocyte Growth Factor/Scatter Factor and Transforming Growth Factor-β1in Mammary Gland Ductal Morphogenesis
• Biphasic effect of transforming growth factor-β1on in vitro angiogenesis
• Pharmacogenetics of CYP2A6, CYP2B6, and UGT2B7 in the Context of HIV Treatments in African Populations
• Effect of 2‐methoxyestradiol treatment on early‐ and late‐stage breast cancer progression in a mouse model
• Global disparities in cystic fibrosis outcomes prior to CFTR modulators: A CF registries cohort study in South Africa and Canada
• Considerations for enhanced mesenchymal stromal/stem cell myogenic commitment in vitro