Pulmonary tuberculosis (PTB) symptomatic individuals, their sociodemographic characteristics, genetic diversity and drug resistance patterns of Mycobacterium tuberculosis strains

This dataset described the entire number of adult holy water sites (HWS) attendees (≥18 years of age) who were screened for Pulmonary Tuberculosis (PTB) -suggestive symptoms at nine selected study zones (HWS) found across the study region. During the study period, a total of 10,313 adult HWS (≥ 18 years of age) were screened, and 560 individuals were PTB symptomatic and participated. Out of 560 PTB symptomatic HWS attendees who participated, 122 (21.8%) were Lowenstein- Jensen (LJ) culture-positive (bacteriologically confirmed cases). Their sociodemographic characteristics and PTB infection risk factors are detailed. All LJ culture-positive isolates were subjected to spoligotyping, resulting in 116 isolates with interpretable spoligo-patterns. We performed drug susceptibility testing for all 122 (LJ culture)-positive isolates using MTBDRplus v2 and MTBDRsl v2 line probe assays.  

Drug-susceptibility testing (DST) results for first and second line anti-TB drugs are detailed in this dataset. Furthermore, a prospective follow-up study on 438 PTB-symptomatic individuals with culture-negative test results was done to determine the prevalence of developing active TB disease subsequent to residing at a HWS. The duration of follow-up was 12 months, starting on the date that a negative culture result was obtained. Thus, 30 (6.8%) were infected with TB and developed active TB disease post-exposure to HWS. In general, in these attached datasets, details of the study participants, LJ culture-testing results, DST results, as well as genotyping findings of the isolates are illustrated.