University of Pretoria

Melvin Ambele

Senior Research Officer (Biological sciences; Biomedical and clinical sciences)

Pretoria, South Africa


  • Sexual Dimorphism in Changes That Occur in Tissues, Organs and Plasma during the Early Stages of Obesity Development
  • Slc7a8 Deletion Is Protective against Diet-Induced Obesity and Attenuates Lipid Accumulation in Multiple Organs
  • Neutral lipids associated with haemozoin mediate efficient and rapid β-haematin formation at physiological pH, temperature and ionic composition
  • The effect of medium supplementation and serial passaging on the transcriptome of human adipose-derived stromal cells expanded in vitro
  • Heterozygosity of p16 expression in an oral squamous cell carcinoma with associated loss of heterozygosity and copy number alterations
  • Insights into the Role of Heme in the Mechanism of Action of Antimalarials
  • Contrasting Views on the Role of Mesenchymal Stromal/Stem Cells in Tumour Growth: A Systematic Review of Experimental Design
  • The Role of Reactive Oxygen Species in Adipogenic Differentiation
  • Synthetic Hemozoin (β-Hematin) Crystals Nucleate at the Surface of Neutral Lipid Droplets that Control Their Sizes
  • Identification of transcription factors potentially involved in human adipogenesis in vitro
  • Amplification of 3q26.2, 5q14.3, 8q24.3, 8q22.3, and 14q32.33 Are Possible Common Genetic Alterations in Oral Cancer Patients
  • Evidence for the exacerbation of lymphedema of geochemical origin, podoconiosis, by onchocerciasis
  • Genome-wide analysis of gene expression during adipogenesis in human adipose-derived stromal cells reveals novel patterns of gene expression during adipocyte differentiation
  • Molecular profile of tongue cancer in an 18‐year‐old female patient with no recognizable risk factor
  • The c-Myc/TBX3 Axis Promotes Cellular Transformation of Sarcoma-Initiating Cells
  • Effects of Antimalarials on Haem Speciation in the Malaria Parasite Plasmodium falciparum
  • Location and Possible Nucleation Face of beta-Haematin Crystals Formed with Lipid
  • Advancing global equity in cancer genomics - challenges and opportunities in Sub-Saharan Africa.
  • Effect of 2-methoxyestradiol treatment on early- and late-stage breast cancer progression in a mouse model
  • Comparative Molecular Genetics of Odontogenic Keratocysts in Sporadic and Syndromic Patients
  • Similarities between tumour immune response and chronic wound microenvironment: Influence of mesenchymal stromal/stem cells
  • Heterogeneity of cell therapy products
  • Who is responsible for protecting my health during the COVID-19 pandemic?
  • Investigating the effects of in vivo silencing of RBBP6 gene on tumor growth in the FVBN-Tg(MMTV PyVT)634MulJ breast cancer mouse model
  • Probing the effects of retinoblastoma binding protein 6 (RBBP6) knockdown on the sensitivity of cisplatin in cervical cancer cells
  • The role of lipid in malaria pigment (Haemozoin) formation under biomimetic conditions
  • MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma
  • The Role of Pref-1 during Adipogenic Differentiation: An Overview of Suggested Mechanisms
  • Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways
  • Barriers to Implementing Clinical Pharmacogenetics Testing in Sub-Saharan Africa. A Critical Review
  • Ameloblastic carcinoma: A systematic review
  • Effect of 2-methoxyestradiol on mammary tumor initiation and progression.
  • Probing the Effects of Retinoblastoma Binding Protein 6 (RBBP6) Knockdown on the Sensitivity of Cisplatin in Cervical Cancer Cells

Melvin Ambele's public data